Fri. Sep 20th, 2019

Prediction of Cerebral Death and Death in Preterm Infants using a Protein in Cord Blood

Preterm babies with the absence of haptoglobin, that is a cell protein, have a greater risk of bleeding in the brain, cerebral palsy and even death, according to some researchers. They have concluded that this protein absence is a potential biomarker pointing out a requirement for greater monitoring and also some preventive interventions.

Doctors, Mr. Catalin Buhimschi and Mrs. Irina Buhimschi conducted research and examined samples of cord blood from 921 newborns in order to observe the association of haptoglobin with poor outcomes in utero inflammation-exposed babies, which is a cause of roughly 30% of preterm births.

They concluded that inflammation-exposed preterm babies lacking haptoglobin had a greater risk of dying before the age of 1 and also the risk of developing cerebral palsy before the age of 2 in comparison to the preterm babies that were saved from the explosion of inflammation. Furthermore, there was a greater risk of bleeding in the brain called intraventricular hemorrhage.

“Our study provides strong evidence that an absence of haptoglobin in preterm babies who have been exposed to inflammation is an indicator of increased risk for complications like brain bleeding, cerebral palsy and even death,” said the corresponding author, Dr. Catalin Buhimschi. “This underscores the potential protective role of haptoglobin against short- and long-term poor neonatal outcomes and suggests that the protein may be a valuable marker of neurologic damage and the need for clinical interventions.”

Catalin and Irina Buhimschi, have previously conducted many types of researches in haptoglobin of preterm babies, However, this is the first time with a huge and representative participant’s sample.

“New mothers and babies are particularly complex and we cannot put all preterm deliveries under the same umbrella,” said Irina Buhimschi. “This study is also particularly fascinating because haptoglobin is a known protein. It’s one that researchers have seen time and again but, until now, has not been applied in this way.”

Mr. Catalin Buhimschi and Dr. Irina Buhimschi for their studies discovered a new method for examining very low-level haptoglobin.

“The takeaway message of this study is that a simple test of cord blood after delivery could help doctors develop an individualized care plan for some at-risk newborns,” Catalin Buhimschi said.